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| Alopecia |
Androgenetic alopecia (male pattern baldness and female pattern baldness) is by far the most common cause of hair loss in men and a serious problem for many women. There are three important elements that are responsible for both male pattern baldness and female:
1. A genetic predisposition for balding to occur.
2. Excessive presence of male hormones.
3. Aging - enough so that the first two factors to occur.
Both men and women produce male hormones that play a useful role in both sexes; but the fact that androgens occur in much higher concentrations in men why male pattern baldness is more common than female pattern baldness is explained.
Root causes of alopecia DHT
Is the metabolism of male hormones (androgen / testosterone), which is the main cause of hair loss and male pattern baldness and female pattern in men and women.
Androgen metabolism includes the enzyme 5-alpha-reductase, which is combined with the hormone (testosterone) and converts it into DHT (dihydro-testosterone). DHT is a natural metabolite of our body.
The cause of male pattern baldness and female
Some people, men and women are genetically predisposed to produce more DHT than the normal individuals. It is this accumulation of DHT and its effect on the cells within the hair follicle and the root, which is one of the main causes of female and male baldness pattern.
When DHT gets into the hair follicle and root, especially a region called the dermal papilla, it changes the cell activity and prevents protein, vitamins and minerals to provide the food necessary for life in the hair of these follicles. Therefore, hair follicles are reproduced at a much slower pace. This reduces their growth phase (anagen phase) and lengthens or resting stage (telogen phase) of the follicle. DHT also causes hair follicles to shrink and gradually become smaller and thinner. This process is known as miniaturization and causes hair loss at the end. DHT induced androgenetic aloepcia is responsible for 95% of all alopecia.
Blocking the synthesis of DHT in molecular level forms the basis for the treatment of hair loss male pattern (male pattern baldness) and APF (female alopecia). There are many natural DHT blockers and a number of drugs that are used for medical hair restoration.
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